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1 What is the difference between Wine and Darwine?

Darwine was the original effort to port Wine to Macs Running macOS and consisted of 2 major efforts.

PowerPC Macs - attempted to integrate QEMU into Wine for x86 CPU emulation
Intel x86

The guide talks about how to run The Old Republic on a Mac machine. From the time I last posted the guide, several things happened. The wine version specified in the guide was very outdated, so I had to move the guide to a newer version of Wine, and with it had to reintroduce an additional step that has to do with using the shell.

Wine Reviews has release information and reviews of Windows applications and games running on Linux Mac OS X and Android using Wine from WineHQ.org Q4Wine PlayOnLinux PlayOnMac WineBottler WineSkin WineTricks and Wine-Staging. Wine is an Open Source implementation of the Windows API on top of X and Unix. MEGA is an easy-to-use sequence alignment/editor and free for MAC with similar tools as BioEdit. It also contains tools for distance and phylogenetic analysis, but it is not a complete 'workbench. Good instructions for installing Wine on Mac are available here. Instructions for Ubuntu are available here. The install process for other distros should be fairly straightforward as well. The TL;DR for intsalling on Mac is to install XQuartz and wine via homebrew: brew install Caskroom/cask/xquartz wine. Create a new wineprefix.

Wine for macOS x86 has now merged into main Wine project, here at WineHQ. Darwine is no longer actively developed.

2 What does Wine on macOS support? (DirectX, DirectSound, Direct3D...)

Sound should be working just fine since Wine release 0.9.15.
MIDI output (via Apple's built-in software synthesizer) works.
3D (OpenGL Support) works. Note that due to Apple's X11 often being outdated, we recommend you install XQuartz, available since 10.5 Leopard, which closely follows Xorg development. Since macOS 10.5.7, Apple X11 may be good and recent enough for wine 3D usage.
Full screen mode works in a Wine release as old as 1.1.24. However, there are too many restrictions to make it generally useful:
Unlike CodeWeaver's X server packaged with their CrossOverMac product, Apple's X11.app will not change the screen resolution. So your app must support your monitor's likely huge native resolution, e.g. 1600x1200. If your app knows only 800x600 and 1024x768, it will not start and may even crash.
Some modern apps, although they may support your monitor's resolution during play, start with logos and intro animations that want to open a screen at 640x480 or 800x600. This will fail and may cause your application not to start at all or even crash. For instance, the game 2weistein - Das Geheimnis des roten Drachen - works well in full screen, yet the screen stays black at start, trying to display the first intro animation, while the subsequent second logo, intro movie and game logo all scale nicely to full screen.
The X11 menu bar will remain visible at all times. The app sees a screen resolution 22 pixel less than it really is, e.g. 1600x1178.
The dock will stay in front of the fullscreen window. Use its auto-hide feature to get rid of it.
'Always on top' windows remain atop Wine's fullscreen window, e.g. window #3 of the CPU% activity meter -- exactly like they do in !TimeMachine's full screen display. Just close or hide them.
Running a Fullscreen program in a Wine Virtual Desktop window should work fine
Starting in Xquartz 2.6.0 (available Oct-Nov 2010), RandR and resolution changing should be working on Macs.
mcicda.dll does not work (bug #20323), so apps will not play music off CD tracks.
Multi-CD installs work, using the `wine eject` command.
More generally, CD-ROM support is incomplete, so Wine will not start many copy-protected apps.

3 How do I change settings?

If you built a plain wine: run /path/to/your/wine winecfg as on any other UNIX.
Audio output will only be enabled after you ran winecfg to configure it.

4 Where are Wine's settings stored?

In your home folder (/Users/<username>/ resp. ~/) in the hidden folder .wine. You can get into (even hidden) folders in the Finder by pressing Shift+Command+G and entering the path, for example ~/.wine.

You can make the hidden folder 'visible' by creating a symbolic link: ln -s ~/.wine wine in Terminal.app.

5 How can I switch the locale?

This Wiki and other Wine documentation mention setting the environment variable LANG. This works for UNIX but deliberately does not work with Wine on MacOS for reasons enumerated in this thread. Instead, set the variable LC_MESSAGES, e.g. use LC_MESSAGES=ja_JP.UTF-8 wine japanese.exe or LC_MESSAGES=ja_JP.SJIS or LC_MESSAGES=fr_FR.UTF-8

6 Will there be a PowerPC version (or will there be a way to run Wine on a PowerPC processor)?

Darwine was the effort to port Wine to PowerPC processors. Darwine is NO LONGER ACTIVELY DEVELOPED.

7 Where can I get a working Wine for Intel Macs?

WineHQ builds packages for macOS 10.8 and higher.
You can compile wine from source with XCode and XQuartz. See macOS/Building for additional troubleshooting and directions.
If you are a Fink or MacPorts user, consider installing the wine or wine-devel package.
you can also check out the Third Party Applications page for info about other Apps that use Wine that may be much easier to use than building Wine yourself. Note that these products are not supported here, so please do not file bugs, submit AppDB test reports, or ask for help on the forum or in IRC if using one.

8 All 16 bit applications crash in winevdm.

This is radar://5935237 bug in Apple's linker, which affects XCode older than 3.2.x. It is reflected in Wine Bug #14920. 32bit apps are not affected. affects

Workarounds:

Build wine yourself with win16 support
- macOS 10.4 Tiger: compile using Xcode 2.x b. macOS 10.5 Leopard: patch Xcode linker bugs, then compile
- download the ld64 linker patch as described in Bug14920 comment29
- apply the ld64 linker patch as described in Bug14920 comment38
macOS 10.6 Snow Leopard or later: compile using Xcode 3.2.x or later

9 How do I right-click in Wine on macOS?

Control-click, as you're probably used to, won't work in wine (so far?). Workaround: Enable secondary click by tapping the trackpad with two fingers. Therefor go to System Preferences > Keyboard & Mouse > Trackpad and enable 'Tap trackpad using two fingers for secondary click'. You can then do the right clicks by tapping the trackpad with two fingers.Update: if you are running a current version of Xquartz, you can go into the X11.app preferences when it's running and select what you want to be modifier keys for right and middle clicks.

10 How come my keyboard shortcuts don't work like normal

Wine by default maps the keys differently than native macOS applications.It's possible to change some of the keyboard mappings depending on the version of wine being used.

Since Wine 1.7.4 its possible to map Option as Alt by adding the following using regedit

Since Wine 3.17 it's possible to map Command as Ctrl meaning CMD+C/CMD+V now functions like Native applications

11 How to launch wine from terminal instead of the wine application?

To do this we need to add the wine application to the PATH variable

To do that we do the following

Then copy in the following

Comment out Wine Stable uncomment out the one you want to be added for use within terminal.To save press Ctrl+X then press Enter to save the file.Now any new terminal session will have wine from available the chosen wine application for the current user.

Install Bioedit On Mac With Wine